A lone scientist, the three-eyed Dr. Emmanuel Cugat, selects five mutants, one male and four females, to be genetically altered, re-sequencing their mutated DNA to restore them to humanity. Belushi, Erin, Angela, Vikki and Lorelei become perfect physical specimens. Dr. Cugat then sends them forth to inspire the shattered Earth. Many of the mutants have other ideas, particularly their nemesis, the monstrous Great Fred.